FIG 5.

Anti-HCV effect of another SQS inhibitor, zaragozic acid A. Huh-7.5.1-8 cells were infected with HCV JFH-1 and then treated with 0 to 60 μg/ml of zaragozic acid A for 4 days. In this experiment, drug treatment was performed in complete medium because the drug was toxic to cells in serum-free medium. (A) The amount of secreted viral particles in each culture supernatant was determined by ELISA for the core protein. (B) Cell viability was determined by XTT assay. Data in each graph are expressed as a percentage of the control value (without the drug) and are means ± SD for triplicate samples from one representative experiment. Similar results were obtained in two independent experiments. Some error bars are not visible due to their small sizes.