FIG 9.

NSW-2012 P dimer interaction with Le^x-tri. (A) Closeup surface and ribbon representation of the NSW-2012–Le^x-tri complex structure, showing the hydrogen bonds with Le^x-tri (salmon-colored sticks) and water-mediated interactions. (B) NSW-2012 and Le^x-tri binding interactions. FUC, α-fucose; NDG, α-N-acetylglucosamine; GAL, β-galactose. The black lines represent the hydrogen bonds, the red line represents the hydrophobic interaction with the hydroxyl group of Tyr444, and the sphere represents water.