Table 7.

Kinetic parameters (V_max and K_m) of enzymatic activities of MAO-A, MAO-B, and COMT in homogenates of brain from WT and renalase KO mice

Brain	WT	KO
MAO-A
Vmax, nmol/mg prot/h	9.88 ± 0.53	13.01 ± 0.69*
Km, μM	630.1 ± 78.76	952.9 ± 115.6
MAO-B
Vmax, nmol/mg prot/h	8.61 ± 0.31	7.58 ± 0.31*
Km, μM	27.9 ± 3.4	27.3 ± 3.9
COMT
Vmax, nmol/mg prot/h	1.47 ± 0.05	0.94 ± 0.04*
Km, μM	7.1 ± 0.8	7.5 ± 1.1

Values represent mean values ± SE; n = 9–11 experiments. Significantly different from corresponding values in WT mice (

^*P < 0.05).