Fig. 5.

Effects of imatinib on 18% cyclic stretch (CS)-induced endothelial dysfunction. HPAEC were treated with imatinib as indicated for 1 h and then subjected to cyclic stretch (18% CS, 24 h). A: representative Western blot for VE-cadherin. B: densitometry of VE-cadherin normalized to β-actin. Data values are means ± SE from 3 independent experiments. (*P < 0.05 compared with control, Dunnett's post hoc test). C: immunofluorescence staining for VE-cadherin. 18% CS in combination with imatinib induced a loss of VE-cadherin from the junctions as indicated by arrows. Representative images from multiple independent experiments are shown.