Fig. 4.

Plasma levels of activated protein C (aPC) in young and aged mice during sepsis. Young and aged male C57BL/6 mice received CLP surgery with a 16G or 21G needle. Age-matched sham-operated mice were used as controls. Plasma aPC level 24 h after surgery was measured by immunocapture assay. This analysis was performed twice in different sets of mice with the similar results. Values are means ± SD; n = 4 to 5. *Statistical significance compared with sham-operated mice of the same age; †statistical significance compared with young mice with 21G CLP; #statistical significance compared with aged mice with 21G CLP. One, two, or three symbols signify P < 0.05, 0.01, or 0.001, respectively.