Table 1.
Comparison of sepsis physiology in young and aged mice with CLP-induced sepsis, indicating unique age-dependent conditions
| Survival | Temperature | White Blood Cell | IL-6 | Creatinine | Surfactant Protein-D | Alanine Aminotransferase | Fibrin | d-Dimer | Plasminogen Activator Inhibitor-1 | Activated Protein C | Protein C | Endothelial Protein C Receptor | Thrombomodulin | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Young mice | ||||||||||||||
| With 21G CLP | ↓ | ↓ | ↓ | ↑ | ↔ | ↑ | (↑) | ↔ | (↑) | ↑ | ↑ | (↓) | ↔ | ↔ |
| With 16G CLP | ↓↓ | ↓↓ | ↓ | ↑↑ | (↑) | ↑ | (↑) | ↔ | (↑) | (↑) | ↑↑ | ↓↓ | ↔ | ↔ |
| Aged mice with 21G CLP | ↓↓ | ↓↓ | ↓ | (↑↑) | ↑* | ↑ | (↑) | ↑↑* | ↑ | ↑ | ↔* | ↔* | ↑* | ↓* |
CLP, cecal-ligation and puncture; 21G, 21-gauge needle; 16G, 16-gauge needle. (↑) or (↓) A modest change without statistical significance;
*
a condition unique to aged mice.