Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 15;2(2):151–166. doi: 10.1002/acn3.158

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

The punctate immunostaining patterns for ubiquitinated proteins, TDP-43, and DUX4-FL in nuclei showed little co-localization. (A–C) Confocal microscope images for ubiquitinated proteins (green, A) and DUX4-FL (red, C) were merged in (B) to show the relatively small regions of overlap (yellow). (B) Includes blue DNA stain for the nucleus. (D–F) Standard microscope images for ubiquitinated proteins (green, D) and TDP-43 (red, F) were merged in (E) and showed little overlap of the punctate areas of immunostaining in the nucleus. (G–I) Standard microscope images for TDP-43 (green, G) and DUX4-FL (red, I) were merged in (H) and showed little overlap of the punctate areas immunostaining seen in the lower DUX4-FL-positive nucleus. Additional examples are in Figure5. The upper DUX4-FL-negative nucleus in (G–I) shows the nearly uniform nuclear immunostaining for TDP-43 that is seen in the absence of DUX4-FL.