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. Author manuscript; available in PMC: 2015 Feb 24.
Published in final edited form as: Adv Cancer Res. 2014;124:131–169. doi: 10.1016/B978-0-12-411638-2.00004-5

Figure 4.1.

Figure 4.1

Schematic representation of the basic molecular-genetic imaging approach. (A) The tissue- or tumor-specific promoter is upstream of the reporter gene, and in the presence of an activator causes transcription of the reporter. (B) In the presence of an inhibitor or silencer or when the activator is low or absent, the reporter gene is not transcribed. (C) The cancer cell expresses the activator and is able to express the reporter. (D) Normal cells do not express the activator and accordingly do not express the reporter. (E) The reporter can be visualized in mice with tumors and potentially in patients with tumors. (F) Normal mice and individuals do not express the reporter.