Table 4.
Effects of HPTP on gastric ulcer induced by indomethacin in rats
| Pre-treatment (5 ml/kg) | Gastric pH | Mucus barrier μg/g tissue | Ulcer area (mm 2 ) | % inhibition |
|---|---|---|---|---|
| Normal (0.5% CMC) | 6.36 ± 0.24* | 27.67 ± 1.97* | ---- | ---- |
| Indomethacin 100 mg/kg | 2.17 ± 0.07 | 7.17 ± 0.21 | 112.32 ± 11.74 | ---- |
| HPTP 50 mg/kg | 3.10 ± 0.18* | 21.97 ± 1.32* | 38.88 ± 2.88* | 65.4 |
| HPTP 100 mg/kg | 4.52 ± 0.17* | 27.48 ± 1.08* | 28.80 ± 2.28* | 74.4 |
| Omeprazole 20 mg/kg | 5.7 ± 0.30* | 28.43 ± 1.45* | 10.08 ± 1.76* | 91.04 |
Values are expressed as Mean ± SEM. (*) indicates significant at P < 0.05 versus indomethacin (ulcerated) group with pre-treatment groups.