Table 1.

Summary of the top-ranked variants, taken from genome-wide searches, for working-memory ability

Authors	N	Measure	Variant	p value	Gene; gene function
Seshadri et al. (2007) [107•]	694	Abstract reasoning	rs1131497	3.2×0-6	SORL1; encodes an LDLR that modulates  APP processing into Aβ, which can  suppress excitatory neuronal activity
Need et al. (2009) [90•]	721	Working-memory  strategy	rs4472969	6.03×10-6	FXYD2; encodes a membrane protein  (Na+, K+-ATPase gamma subunit)  that regulates sodium and  potassium ion transportation
Cirulli et al. (2010) [69•]	514	Animal fluency	rs2247572	6.41×10-7	KCNB2; encodes a type of voltage-gated potassium channel  (Kv2.2) that mediates potassium  ion transportation
		TMT-A	rs17122693	2.55×10-7	ATL1; encodes alastin-1 protein. Disrupted  ATL1 results in age-related  degeneration of dopaminergic neurons  in Drosophila
Papassotiropoulos et al. (2011) [98•]	333discovery 1,699replication	Immediate recall	rs10930201	3.0×10-4a	SCN1A; mediates the construction of a type  of sodium (Na+) channel (Nav1.1)
Knowles et al. (2014) [27•]	1,269	Factor score	rs2467774	1.1×10-5b	HEY1; encodes a protein belonging to the  HES and HEY gene families

Aβ amyloid-β, APP amyloid precursor protein, FDR false discovery rate, HES hairy and enhancer of split, HEYhairy/enhancer-of-split-related with YRPW-like motif, LDLR low-density lipoprotein receptor, TMT-A trail-making test part A

^aFDR corrected

^bLinkage peak-wide corrected