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Summary of selectivity testing of Meprin β hits cisplatin, PPNDS, and NF449.
| Compound | Meprin α | Meprin β | MMP-1 | MMP-2 | MMP-8 | MMP-9 | MMP-13 | MMP-14 | ADAM10 | ADAM17 |
|---|---|---|---|---|---|---|---|---|---|---|
| Cisplatin | >100 | 95±5 | 5.1±0.5 | 5.1±0.6 | NT | 13.9±2.1 | >100 | NT | 4.2±0.2 | 5.1±0.4 |
| PPNDS | 67±4.5 | 0.08±0.005 | NT | 31±2 | 1.0±0.1 | 40±2.5 | 69±4.3 | 73±7 | 19±1.1 | 91±7.1 |
| NF449 | >100 | 0.07±0.005 | NT | 6.0±0.5 | 1.0±0.1 | 8.6±0.7 | 40±3 | 18±1.5 | 1.2±0.1 | 4.6±0.3 |
All units are IC50, μM. n = 3 Mean ± SD.
