Table 2.

Pharmacological inhibitors and protein-based cancer therapeutics.

Inhibitors	Protein	Clinical trial	Cancer type	Ref.
17-AAG	HSP90	Phase I	Breast, solid tumors, lymphoma	[108,119,201]
17-DMAG	HSP90	Phase I	Lung, solid tumors	[120,121,201]
STA-9090	HSP90	Phase II	Non-small-cell lung cancer, gastrointestinal stroma tumor	[99,201]
STA-1474	HSP90	Preclinical	Osteosarcoma	[122]
Geldamycin	HSP90	Phase I	Breast	[123]
CCI-779	mTOR	Phase III, Phase II, Phase I	Breast, endometrial, myeloma, glioma	[124–127]
RAD001	mTOR	Phase III, Phase II	Breast, carcinoid, pancreatic neuroendocrine	[128,129]
AP23573	mTOR	Phase II	Breast	[130]