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. Author manuscript; available in PMC: 2015 Feb 24.
Published in final edited form as: Gen Comp Endocrinol. 2014 Mar 15;203:49–59. doi: 10.1016/j.ygcen.2014.03.003

Figure 2. Roles of KLFs in nuclear receptor signaling.

Figure 2

A) A KLF is a direct transcriptional target of liganded NR that activates or represses secondary response genes. B) A KLF acts as an accessory transcription factor to cooperatively activate or repress an NR target gene. C) A KLF regulates expression of the NR gene to modify cellular sensitivity to hormone.