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. Author manuscript; available in PMC: 2015 Feb 24.
Published in final edited form as: Curr Opin Cell Biol. 2005 Dec 20;18(1):108–116. doi: 10.1016/j.ceb.2005.12.004

Figure 2.

Figure 2

Model of reformation of the nuclear envelope (NE) at the end of mitosis. Chromatin-associated RanGEF creates a gradient of RanGTP around DNA, which induces the localized release of nucleoporins (green balls) chaperoned at mitosis by importin β (orange). Importin α (red) also participates in nuclear formation and is, in part, membrane-associated. Some inner nuclear membrane (INM) proteins (grey), present on membrane, target to the chromatin during assembly. Formation of a closed NE requires incorporation of nuclear pore complexes into the fusing membrane. NE growth requires the addition of more membrane and pores as well as import through the nuclear pore complexes. Additional INM proteins (black), synthesized in the ER, target to the INM via the pore membrane (POM).

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