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. 2014 Dec 20;34(3):307–325. doi: 10.15252/embj.201489847

Figure 7.

Figure 7

Binding of TAB2 NZF to phosphoUb chains
  1. Structure of TAB2 NZF (red) in complex with Lys63 diUb (cyan) [pdb-id 2wwz (Kulathu et al, 2009)]. Ser65 for both Ub moieties is shown as spheres and highlighted with a blue circle.
  2. Pull-down assays with the Lys63-specific TAB2 NZF against different tetraUb (Ub4) species are shown. Phosphorylation of K63 Ub4 does not prevent binding to TAB2 NZF. Met1-linked tetraUb does not interact with TAB2 NZF, independent of Ser65 phosphorylation.