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. 2015 Feb 24;10(2):e0117146. doi: 10.1371/journal.pone.0117146

Table 2. Rating of Clinical Importance.

Rating Range
Small a weighted mean difference (WMD) less than 10% of the scale (e.g., <10 mm on a 100 mm VAS); a standardized mean difference (SMD) or “d” score <0.5; a relative risk of <1.25 or >0.8 (depending on whether the report referred to the risk of benefit or the risk of harm, respectively)
Medium a WMD from 10–20% of the scale; an SMD or “d” score from 0.5 to 0.8; a relative risk between 1.25 and 2.0 or between 0.5 and 0.8 (depending on the factor described above)
Large a WMD >20% of the scale; an SMD or “d” score ≥ 0.8; a relative risk >2.0 or <0.5 (depending on the factor described above)