Fig 5. Bacterial load in immunized mice with S. aureus isolate P bacteremia.
Mice (n = 8) were immunized with the octa-valent vaccine containing IsaA-His6, LytM-His6, Nuc-His6, His6-pro-Atl, and PSMα1-4, or with placebo. Animals were infected by intravenous inoculation of S. aureus isolate P (3 × 105 CFU). At day 14, surviving mice were sacrificed and quantitative cultures of blood, lungs, spleen, liver, and kidneys were performed. Each symbol represents a single mouse. Median values are indicated by horizontal lines. Statistically significant differences in S. aureus load were not observed (P > 0.05; Mann-Whitney U test).