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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Immunol Rev. 2015 Mar;264(1):204–219. doi: 10.1111/imr.12263

Fig. 2. Pattern recognition receptors important for the sensing of mycobacterial PAMPs.

Fig. 2

This schematic shows the major receptors involved in recognition of Mtb and their localization to the surface or the cytoplasm of host cells. PRRs on the surface of cells include TLRs, scavenger receptors, and c-type lectin receptors. Cytoplasmic receptors recognize mycobacterial components, such as secreted proteins and DNA that access the cytoplasm through phagosomal membrane damage. Major signaling pathways are shown including NFκB- and IRF3-dependent cytokine secretion, inflammasome-mediated IL-1β secretion, and the activation of autophagy.