Table 2.

Use of gene therapy to treat osseous defects in large-animal models

Gene product	Vector	Strategy	Model	Ref.
BMP2	Adenovirus	Traditional ex vivo	Goat tibial defect	106, 107
BMP2	Adenovirus	Traditional ex vivo	Horse metacarpus/metatar sus	55
BMP2	Adenovirus	Traditional ex vivo	Goat, osteonecrosis femoral head	108
BMP2	Adenovirus	Traditional ex vivo	Pig cranial defect	109
PTH 1-34	Plasmid- collagen	GAM	Dog femur Horse carpus	74
BMP2, BMP6	Adenovirus	In vivo	Horse metatarsal	69
BMP2	Adenovirus	In vivo	Sheep tibia	71, 72

Abbreviations: BMP, bone morphogenic protein; GAM, gene-activated matrix; PTH, parathyroid hormone.