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. 2015 Feb 15;7:9. doi: 10.1186/s13098-015-0005-8

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© Sanada et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Representative semithin cross section of the sural nerve from normotensive Wistar rat. (A), normotensive Wistar rat with chronically induced diabetes (B), Spontaneously hypertensive rat (C) and Spontaneously hypertensive rat with chronically induced diabetes (D), showing typical endoneural structures. Large (M) and small myelinated fibers are present in the endoneural space. Note the presence of normal endoneural vessels (V) in A and B while in C and D, the vessels show thickening of the walls and reduced lumen. In D, arrows indicate axons with atrophy and arrowheads indicate myelinated fibers with severe myelin disruption. Toluidine blue stained. Bar = 10 μm.