Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 11;8:9. doi: 10.1186/s13041-015-0101-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Choi et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

The effect of alpha-lipoic acid (aLA) on functional recovery. (A) The initial neurological deficit score (NDS) following ischemic stroke was similar for three groups. After treatment with aLA, the NDS was significantly different, with the lowest scores observed for the aLA group (5.09 ± 0.52) when compared with the control group (6.41 ± 0.48, P = 0.001; ANOVA with repeated measures). (B) Artificial occlusion of the MCA resulted in severe impairments in the rotarod performance test. Postoperative motor function in the rotarod test was significantly improved by aLA treatment when compared with the control group (P = 0.013; ANOVA with repeated measures). (C) In the spontaneous motor activity (SMA) test, there was a marked decrease (*P < 0.05; †P < 0.01 as compared to the control; Kruskal-Wallis test) in behavioral efficiency in the ischemic group when compared with sham animals. aLA treatment significantly improved behavioral output. (D) In the flexion test, there was a marked improvement (*P < 0.05 as compared to the control; Mann–Whitney-U test) in the aLA group when compared with the control group. Data represents mean ± SEM (n = 20 in the aLA and control groups, n = 10 in the HNMPA and sham group).