Table 2.
Changes in postprandial insulin after breakfast and dinner at day 1 and day 28
| Placebo (n = 20) | Empagliflozin 10 mg (n = 20) | Empagliflozin 25 mg (n = 19) | |
|---|---|---|---|
| AUC 1–4h for postprandial insulin, μIU · h/ml | |||
| Baseline | 66.4 (63.5)* | 58.9 (55.6) | 65.3 (46.2) |
| Relative change from baseline at day 1 | 1.2 (1.1, 1.3) | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.0) |
| Difference vs placebo (95% CI) | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) | |
| p-value | <0.001 | <0.001 | |
| Relative change from baseline at day 28 | 1.0 (0.9, 1.1) | 0.9 (0.8, 0.9) | 0.8 (0.7, 0.9) |
| Difference vs placebo (95% CI) | 0.9 (0.8, 1.0) | 0.8 (0.7, 0.9) | |
| p-value | 0.074 | 0.002 | |
| AUC 10–13h for postprandial insulin, μIU · h/ml | |||
| Baseline | 73.8 (56.6)† | 60.7 (60.5) | 70.0 (53.7) |
| Relative change from baseline at day 1 | 1.1 (1.0, 1.2) | 0.9 (0.8, 1.0) | 0.9 (0.8, 0.9) |
| Difference vs placebo (95% CI) | 0.8 (0.8, 0.9) | 0.8 (0.7, 0.9) | |
| p-value | 0.002 | <0.001 | |
| Relative change from baseline at day 28 | 1.0 (0.9, 1.0) | 0.8 (0.8, 0.9) | 0.8 (0.7, 0.9) |
| Difference vs placebo (95% CI) | 0.9 (0.8, 1.0) | 0.8 (0.7, 0.9) | |
| p-value | 0.011 | 0.001 |
Log-transformed data. Baseline data are gMean (% gCV), change from baseline data are adjusted gMean ratio (95% CI) based on analysis of covariance (ANCOVA) in the full analysis set. *63.8 (65.5) for day 1 analysis (n = 21). †72.8 (55.5) for day 1 analysis (n = 21).