Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Immunol Rev. 2015 Mar;264(1):138–153. doi: 10.1111/imr.12253

Fig. 2. Antigen uptake and loading in the endosomal pathway.

Fig. 2

The secretory and endosomal pathways have differing characteristics that influence antigen presentation by CD1 proteins (A). After an initial appearance at the cell surface with an endogenous self-lipid, presentation of exogenous lipids by CD1b proteins is accomplished by the trafficking of CD1b proteins and lipid antigens into the lysosome, which has a low pH, contains lipid binding proteins and is enriched in lipids that bind cell surface receptors.