Table 3.
Treatment and outcome of patients with and without sputum SPCN
| SPCN (+) | SPCN (−) | P value | |
|---|---|---|---|
| N = 111 | N = 689 | ||
| Treatment regimen | |||
| Isoniazide (days) | 289 ± 90 | 234 ± 71 | p < 0.001 |
| Rifampicin (days) | 284 ± 91 | 235 ± 69 | p < 0.001 |
| Ethambutol (days) | 228 ± 105 | 191 ± 96 | p = 0.001 |
| Pyrazinamide (days) | 137 ± 136 | 90 ± 74 | p = 0.001 |
| Streptomycin (days) (total cases) | 84 ± 76 (18) | 43 ± 34 (39) | p = 0.036 |
| Levofloxacin (days) (total cases) | 132 ± 141 (11) | 172 ± 196 (17) | p = 0.559 |
| Moxifloxacin (days) (total cases) | 215 ± 120 (6) | 162 ± 146 (13) | p = 0.456 |
| Treatment days after final positive culture | 261 ± 72 | 220 ± 73 | p < 0.001 |
| DOT | 92 (83) | 475 (69) | p = 0.001 |
| Complete treatment | 109 (98) | 679 (99) | p = 0.677 |
| Sputum smear and culture status during treatment | |||
| After treatment for 2 months | |||
| Smear positive | 84 (76) | 32 (5) | p < 0.001* |
| Culture positive | 22 (20) | 50 (7) | p < 0.001* |
| After treatment for 5 months | |||
| Smear positive | 26 (23) | 9 (1) | p < 0.001* |
| Culture positive | 1 (1) | 14 (2) | p = 0.707* |
| After treatment for 9 months | |||
| Smear positive | 6 (5) | 4 (1) | p = 0.001* |
| Culture positive | 0 (0) | 6 (1) | p = 0.407* |
| Relapse within 3 years | 3 (3) | 7 (1) | p = 0.150* |
Data are presented as N (%) or mean ± standard deviation; SPCN, smear-positive but culture-negative; DOT, directly observed therapy.
*Fisher’s exact test.