Table 3. Contractile properties of mdx limb muscles on the FVB (mdx/FVB) versus BL10 background (mdx).
a, values are from the Duan lab studies
b, Data are from 4-m-old mdx4cv mice
mdx/FVB (3 to 6-m-old) |
mdx (2 to 8-m-old) |
References | |
---|---|---|---|
Extensor digitorum longus | |||
Specific twitch force (mN/mm2) | 24.5±2.3 to 27.3±1.2 | 26.6±1.2a to 29.0±1.5a | 26, 27, 28 |
Specific tetanic force (mN/mm2) | 120.4±9.3 to 142.2±7.4 | 129.6±10.5a to 138.5±5.6a | 26, 27, 28 |
Percent force decrease following 10 cycles of eccentric contractions | 47.5±2.5 to 55.5±1.8 | 46.5±4.5a to 70.6±2.7a | 26, 27 |
Tibialis anterior | |||
Specific twitch force (mN/mm2) | 63.5±4.7 to 72.2±2.3 | 27.7±3.0b | 31 |
Specific tetanic force (mN/mm2) | 192.5±10.3 to 206.8±7.1 | 129.5±10.5b to ~200 | 12, 29, 30, 31 |
Percent force decrease following 10 cycles of eccentric contractions | 65.1±5.4 to 78.6±2.0 | 66.4±5.2b | 31 |