Figure 6.

Continuous application of selective α4β2*/α6β2* nAChRs agonists selectively block efferent-mediated excitation of CD afferents while having little effect on α9α10 nAChR-mediated inhibition of bouton afferents. A, C, E, Average response histograms of CD afferents to the standard efferent shock train before and during application of 300 nm varenicline, 30 nm SazA, and 300 nm 5-iodo, respectively. B, D, F, Average response histograms of BT/BM afferents to the standard efferent shock train before and during application of 300 nm varenicline, 30 nm SazA, and 300 nm 5-iodo, respectively. Each series was then followed by the application of 10 μm ICS. Efferent shock trains (20 shocks at 200/s, black bar at t = 0) were repeated every 3 s and all histograms were based on ≥19 shock train presentations.