Figure 8.

Selective blockade of afferent nAChRs can be used to distinguish calyx from dimorphic afferents. Intracellular recordings were obtained from CD afferents during electrical activation of efferent fibers. Efferent shock trains (20 shocks at 200/s, black bar at t = 0) were delivered every 3–5 s. Ensemble means (top, left axis in millivolts) and variances (bottom, right axis in square millivolts) for each unit were based on ≥22 shock train presentations. A, Ensemble mean and variance in a CD afferent in response to the standard efferent shock train during the sequential application of control solution alone (Cntl, black), 100 nm SazA (magenta), and then 10 μm ICS (green). B, Ensemble mean and variance in a CD afferent to the standard efferent shock train before (black) and during (magenta) application of 10 μm DMPP.