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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Immunol. 2015 Jan 26;194(5):2289–2299. doi: 10.4049/jimmunol.1401673

Figure 5. Naïve B7-H1−/− and B7-DC−/− mice exhibit normal survival kinetics and similar PPS3-specific Ig levels following S. pneumoniae respiratory infection.

Figure 5

C57BL/6 WT, B7-H1−/−, and B7-DC−/− mice were challenged i.n. with 105, 106, or 107 CFU WU2 and monitored for signs of morbidity requiring euthanasia. A) Kaplan-Meier survival curves are shown. No significant differences were found based on Log-rank analysis. B) Lung bacterial burdens 3 days post challenge with 107 CFU WU2. C–D) PPS3-specific serum IgM, IgG, and IgA levels in (C) B7-H1−/− and (D) B7-DC−/− mice 14 days post infection with 106 CFU WU2 (n ≥ 5 mice/group).