Table 7.

Percentage of active ligands identified^a in the top 10% ranked compounds using RMSD, single point LGFE and SILCS-MC sampled LGFE ranking alone as well as the consensus ranking using both RMSD and LGFE for the eight targets.

Ranking score	HIVPR	FXa	DHFR	FGFr1	P38 MAP	ADA	ER	AmpC
RMSD	38	25	44	14	17	39	38	10
SP LGFE	19	11	20	16	48	4	85	0
MC LGFE	11	22	20	13	33	4	77	0
RMSD + SP LGFE	42	33	53	29	60	43	85	10
RMSD + MC LGFE	40	42	50	27	47	39	79	10

^aPercentage of active ligands=N_{ligands_in_10%}/N_ligands*100%, where N_{ligands_in_10%} is the number of active ligands identified among the top 10% ranked compounds and N_ligands is the total number of active ligands in the database for the target.