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Relationship between eCrCl and satraplatin pharmacokinetic parameters: apparent clearance (A), exposure (AUC0–24h) (B), peak concentration (C), half life (D). Relationship between patient age (E) and patient weight (F) and satraplatin apparent clearance. Patient with the lowest eCrCl of 102 ml/min/1.73 m2 and lowest satraplatin apparent clearance of 317 ml/min/m2 (depicted here with a ◆) appeared to be an outlier and was excluded from analysis.
