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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Semin Cell Dev Biol. 2014 Sep 27;0:20–25. doi: 10.1016/j.semcdb.2014.09.016

Figure 3.

Figure 3

Changes in thermodynamic parameters between first and second LC8 binding events (ΔΔG°, grey diamonds; ΔΔH°, black circles; and Δ-TΔS°, white squares). Differences in association parameters at different temperatures between LC8 binding to monovalent apo-ICLL and LC8 binding to bivalent ICLL/LC8 (left), and between LC8 binding to monovalent SwaMONOMER and LC8 binding to bivalent SwaDIMER (right). The absence of temperature dependence (ΔΔCp of zero) shows that binding enhancement (ΔΔG°) is not due to enthalpic change (ΔΔH° of zero) but due to entropic change (Δ-TΔS° of same value as ΔΔG°). Figures adapted from [5], and [8].