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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Semin Cell Dev Biol. 2014 Sep 27;0:20–25. doi: 10.1016/j.semcdb.2014.09.016

Figure 6.

Figure 6

Examples of LC8 binding partners having multiple recognition motifs in intrinsically disordered regions. Sequence-based predictions of order, disorder, coiled-coil and LC8 binding motifs are shown for residues 1000 – 2500 of Bassoon, a protein involved in the organization of the cytomatrix at the nerve terminals active zone; the intermediate chain (IC) subunit of the cytoplasmic dynein molecular motor; yeast nucleoporin, Nup159; Chica, a spindle-associated adaptor protein; the flagellar radial spoke protein 3, RSP3, and the Drosophila homologue of ASCIZ (dASCIZ), a DNA damage response and transcription factor. In all these examples, the putative LC8 sites are located within segments with high sequence disorder. Putative motifs are based on the following references: bassoon [21], Nup159 [9], IC[5], Chica[22], RSP3[23] and dASCIZ[24].