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Synthesis of phenoxyacetamide T3SS inhibitors with varying substituents on the phenoxide ring.
Reagents and conditions: (a) ethyl-2-bromopropionate, K2CO3, DMF, 50 °C; (b) KOH, MeOH/H2O, 20 °C; (c) piperonylamine, HATU, DIPEA, DMF, 20 °C; (d) Na metal, ethyl lactate, diglyme, 200 °C.
