Scheme 7.
Synthesis of phenoxyacetamide T3SS inhibitors with multiple optimizations.
Reagents and conditions: (a) ethyl (S)-hydroxybutanoate, DIAD, PPh3, THF, 20 °C; (b) KOH, MeOH/H2O, 20 °C; (c) amine, HATU, DIPEA, DMF, 20 °C.
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