Table 5.
Compound # |
L | secretion IC50 (µM) |
translocation IC50 (µM) |
translocation CC50 (µM) |
---|---|---|---|---|
2 | −NHCH2- | 9.8 ± 2.9 | 6.7 ± 1.0 | 59 ± 16 |
28a | −NH- | >100 | n.d. | n.d. |
28b | −NHCH2CH2- | 12 ± 4 | >17 | 17 ± 11 |
28c | −NHCH2CH2CH2- | >100 | n.d. | n.d. |
28d | −N(Me)CH2- | 28.5 +/−10.6 | n.d. | n.d. |
29a | −OCH2- | >100 | n.d. | n.d. |
29b | −OCH2CH2- | >100 | n.d. | n.d. |
30a | −NHNH- | 47 ± 7 | 23 ± 4 | 35 ± 2 |
30b | −NHNHCH2- | 4.3 ± 0.6 | 8.3 ± 2.3 | 31 ± 1 |
31 | −NHOCH2- | 4.0 ± 0.3 | 24 ± 7 | 59 ± 15 |
33 | −CH2CH2- | >100 | n.d. | n.d. |
n.d.: value not determined