Table 7.
Compound # |
L | Ar | secretion IC50 (µM) |
translocation IC50 (µM) |
translocation CC50 (µM) |
---|---|---|---|---|---|
1 | −NHCH2- | 3,4-methylenedioxyphenyl | 7.8 ± 2.0 | 11 ± 2 | >100 |
2 | −NHCH2- | 4-fluorophenyl | 9.8 ± 2.9 | 6.7 ± 1.0 | 59 ± 16 |
37a | −NHCH2- | benzothiophene-5-yl | 0.9 ± 0.1 | 3.6 ± 0.1 | >100 |
37b | −NHCH2- | indole-5-yl | 0.8 ±-0.1 | 1.9 ± 0.2 | >100 |
37c | −NHCH(CH2OH)- | 4-fluorophenyl | 6.9 ± 0.2 | 29.3 ± 3.2 | 75 ± 21 |