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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Semin Cell Dev Biol. 2014 Sep 22;0:73–81. doi: 10.1016/j.semcdb.2014.09.013

Figure 4.

Figure 4

Putative roles for SHP2 in embryonic Left-Right (LR) patterning and cardiac looping.

Embryonic cardiac laterality and related cardiac looping are governed by both tissue-extrinsic (top panel) and tissue-intrinsic (bottom panel) mechanisms. In the mouse node, a leftward nodal flow is generated by coordinated movements of cilia. This flow creates an asymmetric distribution of calcium and morphogens to the left side of the embryo, driving the expression of Nodal and subsequent effectors of LR patterning. SHP2 is involved in both FGF-mediated signaling and regulation of calcium. Therefore, SHP2 may not only participate in both cilia biogenesis and function, but also in the release of vesicles containing the morphogens.