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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Semin Cell Dev Biol. 2014 Sep 19;0:119–126. doi: 10.1016/j.semcdb.2014.09.005

Fig. 2. Dramatic alterations of tracheal tube morphology produced by loss of R3 RPTP activity and hyperactivation of RTK signaling.

Fig. 2

(A) Four segments of the normal tracheal network in a Drosophila embryo. (B) Four segments of the tracheal network in a Ptp4E Ptp10D double mutant embryo that also expresses an activated mutant EGFR (EgfrEllipse) in tracheal cells. Note that all tracheal branches are converted to large bubble-like cysts, except for the multicellular dorsal trunk (large horizontal tube at the top), which is relatively unaffected. Expression of EgfrEllipse in a wild-type embryo produces no cysts. For further information and diagrams and images of wild-type and mutant tracheae, see (Jeon et al., 2012; Jeon and Zinn, 2009).