Table 1. Differentially expressed genes (FDR-adjusted P-value < 2XE-9) across activity-genotype contrasts.
| Gene Name* | Log2Fold 1 | FDR-adjusted P-Value | |||||
|---|---|---|---|---|---|---|---|
| AM-AW 3 | AM-IM 4 | AW-IM 2 | IW-IM 7 | IW-AW 5 | IW-AM 6 | ||
| Mettl21e | 2.72 | 0.57 | 3.29 | 4.48 | -1.19 | -3.91 | 1.55E-13 |
| Dusp18 | -0.78 | -0.73 | -1.51 | -0.64 | -0.87 | -0.09 | 1.55E-13 |
| Per1 | 1.22 | 0.40 | 1.62 | 0.82 | 0.79 | -0.42 | 1.55E-13 |
| Atp1b2 | 0.62 | 0.34 | 0.96 | 0.31 | 0.65 | 0.023 | 1.55E-13 |
| Tnnc1 | -0.89 | -4.14 | -5.03 | -3.67 | -1.36 | -0.47 | 1.55E-13 |
| Zmynd17 | -1.25 | 0.47 | -0.78 | -1.63 | 0.85 | 2.09 | 1.55E-13 |
| Myh7 | -0.72 | -4.87 | -5.58 | -4.37 | -1.20 | -0.49 | 1.55E-13 |
| Tpm3 | -0.75 | -2.22 | -2.96 | -1.76 | -1.20 | -0.46 | 1.55E-13 |
| Ddah1 | -1.64 | 0.08 | -1.57 | -2.15 | 0.59 | 2.23 | 1.55E-13 |
| Myl2 | -1.15 | -3.74 | -4.89 | -3.49 | -1.39 | -0.25 | 1.55E-13 |
| Atp2a2 | -0.89 | -2.15 | -3.05 | -2.31 | -0.74 | 0.16 | 1.55E-13 |
| Pak1 | 0.56 | -0.09 | 0.46 | 1.07 | -0.60 | -1.16 | 1.55E-13 |
| Tnnt1 | -0.92 | -4.07 | -4.99 | -3.66 | -1.33 | -0.41 | 1.55E-13 |
| Csrp3 | -0.91 | -1.92 | -2.83 | -2.01 | -0.82 | 0.09 | 1.55E-13 |
| Fxyd6 | -0.76 | -2.05 | -2.81 | -1.96 | -0.85 | -0.08 | 1.55E-13 |
| Myoz2 | -0.59 | -2.43 | -3.03 | -2.12 | -0.91 | -0.31 | 6.84E-13 |
| Myl3 | -0.62 | -3.15 | -3.77 | -2.76 | -1.01 | -0.39 | 6.84E-13 |
| Naca | 0.87 | 0.03 | 0.91 | 0.43 | 0.48 | -0.39 | 1.89E-12 |
| Ak3 | 0.55 | -1.53 | -0.99 | 0.41 | -1.40 | -1.95 | 1.89E-12 |
| Cyp1a1 | 2.04283 | -0.84607 | 1.19676 | 0.267273 | 0.929775 | -1.11319 | 3.16E-12 |
| Grem2 | 1.44986 | 0.213147 | 1.66277 | 2.52511 | -0.86228 | -2.31217 | 3.16E-12 |
| Fos | -0.78073 | 0.039794 | -0.74082 | -1.52664 | 0.786004 | 1.56659 | 8.48E-12 |
| Gnb2l1 | 0.739797 | -0.36408 | 0.375364 | -0.32355 | 0.699348 | -0.04009 | 8.56E-12 |
| Wnk2 | 1.10552 | 0.056718 | 1.16275 | 0.760786 | 0.402344 | -0.70346 | 2.45E-11 |
| Tmem100 | -0.76578 | 0.050259 | -0.71569 | -1.11695 | 0.401146 | 1.16691 | 3.02E-11 |
| Ncor2 | 0.556591 | -0.14625 | 0.41082 | -0.02854 | 0.439626 | -0.11714 | 6.96E-11 |
| Acta2 | 0.972604 | -0.62395 | 0.348594 | -0.39031 | 0.738874 | -0.23374 | 2.01E-10 |
| Pmepa1 | -0.67603 | -0.0258 | -0.70168 | -1.02573 | 0.324245 | 1.00005 | 2.01E-10 |
| Sln | 1.5134 | 0.156663 | 1.67004 | 2.36704 | -0.69664 | -2.21015 | 2.90E-10 |
| Dhcr24 | 0.771441 | -0.05624 | 0.715401 | -0.12054 | 0.83638 | 0.064728 | 3.20E-10 |
| Dusp23 | 0.468437 | 0.024808 | 0.493519 | 0.026371 | 0.467286 | -0.00141 | 1.01E-09 |
| Ramp1 | -0.66605 | -0.05061 | -0.71666 | -0.92948 | 0.213069 | 0.87899 | 1.07E-09 |
| Atrnl1 | -0.67904 | -0.04955 | -0.72883 | -0.49233 | -0.2365 | 0.442585 | 1.32E-09 |
| Lancl1 | -1.22412 | 0.08892 | -1.13543 | -1.33056 | 0.195232 | 1.41926 | 1.43E-09 |
* Genes exhibiting significant synergistic and antagonist activity-by-genotype interaction effects are displayed in italics. Ddha1, Lancl1, Fos, Tmem1, and Pmepa1 follow a synergistic pattern; Sln, Grem2, Mettl2, and Pak1 follow an antagonistic pattern.
1. When considering two values, A and B, Log2Fold Change = Log2 (B/A). For example, Log2Fold of the contrast AW-IM = log2(IM/AW).
2. AW-IM refers to the active wild-type vs. inactive myostatin-reduced contrast group
3. AM-AW refers to the active myostatin-reduced vs. active wild-type contrast group
4. AM-IM refers to the active myostatin-reduced vs. inactive myostatin-reduced contrast group
5. IW-AW refers to the inactive wild-type vs. active wild-type contrast group
6. IW-AM refers to the inactive wild-type vs. active myostatin-reduced contrast group
7. IW-IM refers to the jnactive wild-type vs. inactive myostatin-reduced contrast group
*Expanded gene names, listed in alphabetical order: Acta2 = actin, alpha 2, smooth muscle, aorta; Ak3 = adenylate kinase 3; Atp1b2 = ATPase, Na+/K+ transporting, beta 2 polypeptide; Atp2a2 = ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Atrnl1 = Attractin-Like 1; Csrp3 = cysteine and glycine-rich protein 3; Cyp1a1 = Cytochrome P450, Family 1, Subfamily A, Polypeptide 1; Ddah1 = dimethylarginine dimethylaminohydrolase 1; Dhcr24 = 24-Dehydrocholesterol Reductase; Dusp18 = dual specificity phosphatase 18; Dusp23 = Dual Specificity Phosphatase 23; Fos = FBJ Murine Osteosarcoma Viral Oncogene Homolog; Fxyd6 = FXYD domain-containing ion transport regulator 6; Gnb2l1 = Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2-Like; Grem2 = Gremlin 2, DAN Family BMP Antagonist; Lancl1 = LanC Lantibiotic Synthetase Component C-Like 1; Mettl21e = methyltransferase like 21E; Myh7 = myosin, heavy chain 7, cardiac muscle, beta; Myl2 = myosin, light polypeptide 2, regulatory, cardiac, slow; Myl3 = myosin, light polypeptide 3; Myoz2 = myozenin 2; Naca = nascent polypeptide-associated complex alpha polypeptide; Ncor2 = Nuclear Receptor Corepressor 2; Pak1 = p21 protein (Cdc42/Rac)-activated kinase 1
Per1 = period circadian clock 1; Pmepa1 = Prostate Transmembrane Protein, Androgen Induced 1; Ramp1 = Receptor (G Protein-Coupled) Activity Modifying Protein 1; Sln = Sarcolipin; Tmem100 = Transmembrane Protein 100; Tnnc1 = troponin C, cardiac/slow skeletal; Tnnt1 = troponin T1, skeletal, slow; Tpm3 = tropomyosin 3, gamma; Wnk2 = WNK Lysine Deficient Protein Kinase 2; Zmynd17 = zinc finger, MYND-type containing 17