Table 4. Enriched (enrichment score > 3.0) clusters of Gene Ontology (GO) biological process (BP), molecular function (MF) Functional Annotation Tool (FAT) categories, and KEGG pathways among the genes exhibiting the profile characterized by under-expressed in active wild-type vs inactive myostatin-reduced and in active myostatin-reduced vs inactive myostatin-reduced and not differentially expressed in all other contrasts.

Category	Term	Number of Genes	P-Value	FDR-adjusted P-value
Score = 16.28
KEGG PATHWAY	mmu00190:Oxidative phosphorylation	31	6.69E-33	6.84E-30
KEGG PATHWAY	mmu05012:Parkinson’s disease	30	6.01E-31	6.14E-28
GOTERM BP FAT	GO:0022900~electron transport chain	24	1.58E-27	2.39E-24
KEGG PATHWAY	mmu05010:Alzheimer’s disease	30	9.82E-27	1.00E-23
KEGG PATHWAY	mmu05016:Huntington’s disease	30	1.16E-26	1.19E-23
GOTERM BP FAT	GO:0006091~generation of precursor metabolites and energy	29	2.84E-25	4.30E-22
GOTERM BP FAT	GO:0055114~oxidation reduction	32	3.95E-17	5.99E-14
GOTERM MF FAT	GO:0015078~hydrogen ion transmembrane transporter activity	12	1.27E-11	1.65E-08
GOTERM MF FAT	GO:0015077~monovalent inorganic cation transmembrane transporter activity	12	2.47E-11	3.20E-08
GOTERM MF FAT	GO:0022890~inorganic cation transmembrane transporter activity	12	1.55E-09	2.01E-06
KEGG PATHWAY	mmu04260:Cardiac muscle contraction	10	2.24E-07	2.29E-04
GOTERM MF FAT	GO:0015002~heme-copper terminal oxidase activity	6	5.10E-07	6.61E-04
GOTERM MF FAT	GO:0016675~oxidoreductase activity, acting on heme group of donors	6	5.10E-07	6.61E-04
GOTERM MF FAT	GO:0016676~oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	6	5.10E-07	6.61E-04
GOTERM MF FAT	GO:0004129~cytochrome-c oxidase activity	6	5.10E-07	6.61E-04