Table 10. Enriched (enrichment score > 8.0) clusters of Gene Ontology (GO) biological process (BP), molecular function (MF) Functional Annotation Tool (FAT) categories, and KEGG pathways among the genes differentially expressed between active and inactive mice (FDR-adjusted P-value < 0.05).

Category	Term	Number of Genes	P-Value	FDR-adjusted P-value
Score = 19.79
KEGG PATHWAY	mmu00190:Oxidative phosphorylation	51	5.29E-29	6.39E-26
KEGG PATHWAY	mmu05012:Parkinson’s disease	50	2.05E-27	2.47E-24
GOTERM BP FAT	GO:0006091~generation of precursor metabolites and energy	65	2.35E-27	4.12E-24
KEGG PATHWAY	mmu05010:Alzheimer’s disease	55	7.43E-25	8.98E-22
KEGG PATHWAY	mmu05016:Huntington’s disease	53	5.65E-23	6.82E-20
GOTERM BP FAT	GO:0022900~electron transport chain	39	4.30E-22	7.54E-19
GOTERM MF FAT	GO:0015078~hydrogen ion transmembrane transporter activity	23	4.07E-11	6.28E-08
GOTERM MF FAT	GO:0015077~monovalent inorganic cation transmembrane transporter activity	23	1.44E-10	2.22E-07
GOTERM MF FAT	GO:0022890~inorganic cation transmembrane transporter activity	26	2.46E-09	3.79E-06
Score = 8.42
KEGG PATHWAY	mmu04260:Cardiac muscle contraction	28	1.13E-14	1.35E-11
GOTERM MF FAT	GO:0015078~hydrogen ion transmembrane transporter activity	23	4.07E-11	6.28E-08
GOTERM MF FAT	GO:0015077~monovalent inorganic cation transmembrane transporter activity	23	1.44E-10	2.22E-07
GOTERM MF FAT	GO:0022890~inorganic cation transmembrane transporter activity	26	2.46E-09	3.79E-06
GOTERM MF FAT	GO:0016675~oxidoreductase activity, acting on heme group of donors	10	7.32E-07	1.13E-03
GOTERM MF FAT	GO:0016676~oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	10	7.32E-07	1.13E-03
GOTERM MF FAT	GO:0015002~heme-copper terminal oxidase activity	10	7.32E-07	1.13E-03
GOTERM MF FAT	GO:0004129~cytochrome-c oxidase activity	10	7.32E-07	1.13E-03