Table 2. Fibrotic Bronchi: Major Changes in Gene Expression.
| Gene | Gene Description | Fold Increase a |
|---|---|---|
| Nkain1 | Na+/K+ transporting ATPase interacting 1 | 29.7 |
| Spp1 | secreted phosphoprotein 1 | 29.6 |
| Crabp2 | cellular retinoic acid binding protein 2 | 27.6 |
| Cma1 | chymase 1, mast cell | 19.2 |
| Lamb3 | Laminin, beta 3 | 18.9 |
| Plau | plasminogen activator, urokinase | 18.3 |
| Thbs2 | Thrombospondin 2 | 17.4 |
| Tmem178 | Transmembrane protein 178 | 16.6 |
| Tgm1 | transglutaminase 1, K polypeptide | 16.4 |
| Bcat1 | Branched chain aminotransferase 1, cytosolic | 15.7 |
| Plaur | urokinase plasminogen activator receptor | 15.4 |
| Serpine1 | serpin peptidase inhibitor, clade E, member 1 | 15.0 |
| Angptl4 | Angiopoietin-like 4 | 14.6 |
| Inhba | inhibin beta-A | 14.2 |
| Wisp1 | WNT1 inducible signaling pathway protein 1 | 13.4 |
| Fold Decrease a | ||
| Sec14l3 | SEC14-like 3 (S. cerevisiae) | -90.4 |
| Pon1 | Paraoxonase 1 | -40.0 |
| Fmo2 | Flavin containing monooxygenase 2 | -34.9 |
| Ces1d | carboxylesterase 1D | -33.7 |
| Cyp4b1 | cytochrome P450, family 4, subfamily b, polypeptide 1 | -29.6 |
| Gsta5 | Glutathione S-transferase Yc2 subunit | -25.1 |
| Gpr155 | G protein-coupled receptor 155 | -23.7 |
| Slc15a2 | solute carrier family 15 (H+/peptide transporter), member 2 | -23.3 |
| Cyp2f4 | cytochrome P450, family 2, subfamily f, polypeptide 4 | -21.0 |
| Klhl38 | Kelch-like 38 (Drosophila) | -20.9 |
| S100a1 | S100 calcium binding protein A1 | -20.5 |
| Cyp2b1 | Cytochrome P450, family 2, subfamily b, polypeptide 1 | -20.0 |
| Cdh29 | Cadherin-like 29 | -20.0 |
| T2 | Brachyury 2 | -19.1 |
| Hap1 | Huntington-associated protein 1 | -17.9 |
aFold change relative to air-exposed controls