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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Free Radic Biol Med. 2014 Nov 29;0:292–299. doi: 10.1016/j.freeradbiomed.2014.11.009

Table 2.

NRF2 as an independent prognostic factor in cancer patients.

CNC Family Tumor Type Observation Method Other Variables for Multivariate Analysis Reference
NRF2/Keap1 NSCLC (patients: 122) NRF2 high/Keap1 low
Poor OS, RFS 		IHC

  • Age at surgery

  • Tumor Stage

  • Smoking

 [46]
NRF2 Increased nuclear expression
Poor OS, RFS
HNSCC (patients: 60) Increased mutant NRF2 signatures
Poor OS		 Microarray [47]
NSCLC (patients: 60) Increased expression
Poor OS, PFS 		IHC Not Significant [48]
Lung Cancer (patients: 109) Increased NRF2 expression
Poor DSS		 IHC [49]
Lung Cancer (patients: 289) Increased NRF2 expression
Poor OS		 IHC [50]
Gallbladder Cancer (patients: 59) Increased expression
Poor OS 		IHC

  • Metastasis

 [52]
Epithelial Ovarian Cancer (patients: 30) Increased NRF2 pathway
Poor OS		 Microarray [53]
Breast Cancer (patients: 452) rs2886162 genotype AA
Poor OS 		SNP Genotyping

  • Nodal Status

  • HER2 Status

 [55]
Bladder Cancer (patients: 225) Increased NRF2 expression
Poor OS, DSS, RFS		 IHC [56]
Gastric Cancer (patients: 186) Increased NRF2 expression
Poor OS, DFS 		IHC

  • TNM stage (DFS only)

 [58]
Glioblastoma (patients: 68) Increased NRF2 expression
Poor OS 		IHC

  • HIF1α

  • Resection Degree

 [59]
Glioblastoma (patients: 49) Increased NRF2 expression
Poor OS		 IHC [60]
Pancreatic Adenocarcinoma (patients: 103) Increased nuclear expression
Poor OS		 IHC [61]
SCLC (patients: 262) NFE2L2 Mutation
Poor OS 		PCR

  • Pathological Stage

 [149]
Lung Adenocarcinoma (patients: 387) NFE2L2 SNP Homozygous (c.617>A/A)
Poor OS		 SNP Genotyping [150]

OS: Overall Survival, RFS: Recurrence Free Survival, PFS: Progression Free Survival, DSS: Disease Specific Survival; significance from Kaplan-Meier method, Highlighted in Red, OS: Overall Survival, RFS: Recurrence Free Survival, PFS: Progression Free Survival, DFS: Disease Free Survival; Independent prognostic factor using multivariate analysis, HNSCC: Head and Neck Squamous Cell Carcinoma, NSCLC: Non-Small Cell Lung Carcinoma, SCLC: Squamous Cell Lung Cancer, IHC: Immunohistochemistry, SNP: Single Nucleotide Polymorphism, TNM: Tumor Node Metastasis