Table 1. Anthropometric and body composition in obese adolescents with (NAFLD +) and without NAFLD (NAFLD −).
| NAFLD − | NAFLD + | P | |
|---|---|---|---|
| n | 12 | 12 | |
| IHTG (%) | 1.5 ± 0.3 | 9.4 ± 0.9 | <0.001 |
| Male/female (n) | 7/5 | 7/5 | |
| Black/white (n) | 2/10 | 2/10 | |
| IGT (n)* | 2 | 4 | 0.640 |
| Age (yrs) | 14.6 ± 0.4 | 15.1 ± 0.4 | 0.340 |
| Tanner stage, 3/4/5 (n) | 3/1/8 | 0/2/10 | 0.169 |
| BMI (kg/m2) | 34.6 ± 1.1 | 38.1 ± 1.4 | 0.059 |
| Waist circumference (cm) | 108.5 ± 2.4 | 119.5 ± 2.2 | 0.003 |
| Body fat (%) | 44.0 ± 1.3 | 44.9 ± 1.4 | 0.652 |
| Fat free mass (kg) | 52.6 ± 2.8 | 58.8 ± 1.8 | 0.078 |
| Visceral AT (cm2) | 68.7 ± 5.5 | 90.1 ± 7.8 | 0.038 |
| Abdominal SAT (cm2) | 472.7 ± 43.1 | 586.2 ± 38.4 | 0.062 |
| Cholesterol (mg/dl) | 133.2 ± 6.8 | 165.4 ± 8.2 | 0.006 |
| Triglycerides (mg/dl) | 75.7 ± 7.4 | 135.6 ± 18.5 | 0.007 |
| HDL (mg/dl) | 37.4 ± 1.9 | 40.2 ± 2.6 | 0.391 |
| LDL (mg/dl) | 80.7 ± 6.2 | 98.1 ± 7.3 | 0.082 |
| VLDL (mg/dl) | 15.1 ± 1.5 | 27.1 ± 3.7 | 0.007 |
| ALT (IU/l)** | 18.9 ± 1.8 | 35.4 ± 4.6 | 0.005 |
| AST (IU/l)** | 21.4 ± 1.3 | 28.8 ± 2.8 | 0.035 |
| OGTT variables | |||
| Fasting glucose (mg/dl) | 89.0 ± 1.4 | 90.0 ± 2.1 | 0.691 |
| Fasting insulin (μU/ml) | 22.3 ± 2.7 | 36.9 ± 4.9 | 0.016 |
| Glucose at 120 min (mg/dl) | 116.3 ± 5.1 | 137.1 ± 5.8 | 0.014 |
| Insulin at 120 min (μU/ml) | 77.6 ± 9.3 | 244.1 ± 52.5 | 0.005 |
| Glucose AUC (mg·min/dl) | 15125.4 ± 481.3 | 16818.8 ± 623.7 | 0.043 |
| Insulin AUC (μU·min/ml) | 12382.6 ± 1142.1 | 24157.9 ± 3843.4 | 0.008 |
| Insulinogenic Index | 2.6 ± 0.5 | 3.4 ± 0.7 | 0.376 |
| OGTT-Disposition Index | 0.12 ± 0.01 | 0.10 ± 0.02 | 0.499 |
Mean ± SEM. IHTG, intrahepatic triglyceride; IGT, impaired glucose tolerance; SAT, subcutaneous adipose tissue; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUC, area under the curve.
*
2-hr post-OGTT glucose of ≥140–199 mg/dl according to ADA criteria (21).
**
n=10 (NAFLD−).