Table 5.
Demographic and clinical characteristics of Cowden syndrome and Cowden syndrome-like patients with endometrial cancer stratified by germline SDHB/C/D variation status (n=367).
| Variable | SDHx variant Negative N=331 | SDHx variant Positive N=36 | p-value | |
|---|---|---|---|---|
| Age | Mean Range |
53.0 21–88 |
55.0 21–86 |
0.36 |
| Histology | Endometrioid Serous/clear cell Mucinous Sarcoma NOS*/Unknown |
139 (42%) 15 (5%) 1 (0.3%) 9 (3%) 167 (51%) |
14 (39%) 4 (11%) 0 1 (3%) 17 (47%) |
0.69 |
| Race | White African American Asian Other Unknown |
195 (59%) 7 (2%) 8 (2%) 19 (6%) 102 (31%) |
22 (61%) 2 (6%) 0 2 (6%) 10 (28%) |
0.63 |
| Uterine Fibroid | Yes No/unknown |
121 (37%) 210 (63%) |
16 (44%) 20 (56%) |
0.45 |
| Breast Cancer | Yes No/unknown |
202 (61%) 129 (39%) |
23 (64%) 13 (36%) |
0.73 |
| Renal cancer | Yes No/unknown |
15 (5%) 315 (95%) |
2 (6%) 34 (94%) |
0.73 |
| Thyroid cancer | Yes No Unknown |
46 (14%) 285 (86%) |
5 (14%) 31 (86%) |
0.99 |
| Macrocephaly | Yes No |
75 (23%) 256 (77%) |
5 (14%) 31 (86%) |
0.31 |
| Cleveland Clinic Score |
Mean Median |
9.1 7 |
7.8 6 |
0.38 |
| PTEN protein level | PTEN Q1 PTEN Q2 PTEN Q3 PTEN Q4 |
59 (26%) 55 (25%) 54 (23%) 56 (25%) |
8 (36%) 4 (18%) 6 (27%) 4 (18%) |
0.67 |
*
Not otherwise specified