Table 6.
Demographic and clinical characteristics of Cowden syndrome and Cowden syndrome-like patients with endometrial cancer stratified by germline KLLN promoter methylation status (n=228).
| Variable |
KLLN_Me+ N=24 |
KLLN_Me− N=204 |
p-value | |
|---|---|---|---|---|
| Age | Mean Range |
44 21–66 |
52 21–86 |
0.018 |
| Histology | Endometrioid Serous/clear cell Mucinous Sarcoma NOS*/Unknown |
6 (25%) 1 (4%) 0 0 17 (71%) |
87 (17%) 8 (4%) 0 1 (1%) 105 (51%) |
0.35 |
| Race | White African American Asian Other Unknown |
12 (50%) 0 0 2 (8%) 10 (42%) |
106 (52%) 3 (2%) 5 (3%) 13 (6%) 77 (38%) |
0.88 |
| Uterine Fibroid | Yes No/unknown |
8 (33%) 16 (67%) |
73 (36%) 131 (64%) |
0.8 |
| Breast Cancer | Yes No/unknown |
13 (54%) 11 (46%) |
122 (60%) 82 (40%) |
0.75 |
| Renal cancer | Yes No/unknown |
3 (12.5%) 21 (87.5%) |
10 (5%) 194 (95%) |
0.12 |
| Thyroid cancer | Yes No/ Unknown |
5 (21%) 19 (79%) |
28 (14%) 176 (86%) |
0.52 |
| Macrocephaly | Yes No |
10 (42%) 14 (58%) |
53 (26%) 151 (74%) |
0.10 |
| Cleveland Clinic score | Mean Median |
14 16 |
10.5 8 |
0.01 |
| PTEN protein level | PTEN Q1 PTEN Q2 PTEN Q3 PTEN Q4 |
6 (33%) 3 (17%) 6 (33%) 3 (17%) |
47 (31%) 35 (23%) 39 (26%) 31 (20%) |
0.85 |
*
Not otherwise specified