Table 2.

Sensitivities, specificities and positive predictive values (PPVs) for tuberculosis within 1 year postpartum associated with cut-off values in IFN-γ response measured at 32 weeks’ gestation in HIV-1 infected women.

Predictor	Cut-off value	Events	PYFU	Sensitivity (95% CI)	Specificity (95% CI)	Positive Predictive value (95% CI)	AUC (95% CI)	Hazard Ratio* (95% CI)	p-value
IFN-γ	>0	7	164.3	78.9 (47.8–100.0)	35.7 (30.3–41.4)	4.3 (1.7–8.8)	0.57 (0.41–0.69)	1.9 (0.4–9.3)	0.41
	≥ 6	7	118.7	77.7 (45.7–100.0)	54.6 (49.3–60.1)	5.9 (2.4–12.2)	0.66 (0.50–0.78)	4.0 (0.8–19.3)	0.08
	≥ 10	6	102.1	65.0 (29.0–98.7)	60.5 (55.2–65.7)	5.9 (2.2–12.8)	0.63 (0.45–0.80)	3.0 (0.7–12.0)	0.12
ESAT-6	>0	6	148.6	69.1 (36.3–100.0)	41.3 (35.9–46.8)	4.0 (1.5–8.8)	0.55 (0.37–0.70)	1.4 (0.4–5.7)	0.61
	≥ 6	6	101.8	67.4 (30.7–98.0)	61.2 (56.1–66.8)	5.9 (2.2–12.8)	0.64 (0.45–0.80)	3.0 (0.8–12.1)	0.12
	≥ 10	5	86.7	55.5 (21.3–90.2)	66.2 (60.8–71.5)	5.8 (1.9–13.5)	0.61 (0.43–0.79)	2.4 (0.7–9.1)	0.18
CFP-10	>0	7	143.9	78.9 (44.1–100.0)	43.9 (38.3–49.1)	4.9 (2.0–10.0)	0.61 (0.46–0.74)	2.7 (0.6–13.1)	0.21
	≥ 6	6	93.6	66.0 (28.5–99.2)	63.4 (57.7–68.6)	6.4 (2.4–14.0)	0.65 (0.46–0.82)	3.4 (0.9–13.8)	0.08
	≥ 10	5	76.7	50.5 (13.9–85.2)	69.8 (64.7–74.8)	6.5 (2.1–15.2)	0.60 (0.43–0.78)	2.9 (0.8–10.8)	0.11

Note: PYFU Person years of follow-up; CI Confidence Interval

^*Crude Hazard Ratio for active TB in women above IFN-γ cut-off value compared with women below IFN-γ cut-off value