FIGURE 1:

Pathogenesis of severe EGFR-driven growth and VDR loss. (A) TGFα/EGFR induction of AP2 and LIP synthesis exacerbate growth and VDR loss through TGFα gene upregulation and VDR gene downregulation. (B) Structure of the C/EBPβ mRNA and protein isoforms: a single C/EBPβ mRNA encodes (darker lane) for three distinct proteins C/EBPβ* (LAP1), C/EBPβ (LAP2) and dominant negative C/EBPβ (LIP) through their translation initiation (AUG) from three distinct in-frame translation sites. TGFα induces LIP translation through activation and binding of CUG-BP1 to the third in frame AUG. The protein diagram indicates transactivation, DNA-binding and leucine zipper regions.