FIGURE 2:

Parathyroid-specific EGFR inactivation prevents parathyroid hyperplasia upon NX. Bars and error bars represent the mean and SEM of serum BUN (A, r² = 0.50), FGF23 (B, r² = 0.24) calcium (black bars) and phosphate (gray bars) (C, r² = 0.26 and 0.19, respectively), parathyroid gland volume/body weight (D, r² = 0.42), cell number per PTG area (E, r² = 0.62) and serum PTH (F, r² = 0.55) in WT and dnEGFRm mice after 14 weeks of either 75% NX or sham operation. *, ** or *** indicate P < 0.05, P < 0.01 or P < 0.001 versus sham WT; ## indicates P < 0.01 versus sham dnEGFRm; ^ and ^^ indicate P < 0.05 and P < 0.01 versus NX WT and r² measures the goodness of fitness using the linear regression model described in ‘Materials and methods’ section. No significant interaction between NX and the transgene was found. Sham WT: n = 5; sham dnEGFRm: n = 3; NX WT: n = 11 and NX dnEGFRm: n = 10, where n is the number of mice and also the number of parathyroid glands examined.