Table 1.

Published outcome for severe congenital anomalies often described as lethal.^a

Severe congenital anomalies	Prevalence	Probability of live birth (in absence of termination)	Median postnatal survival	Proportion surviving >1 week/>1 year	Longest reported survivals
Renal agenesis	1.7/10,000 [23]	Not reported	<24 h [23]	<5%	13 months [97,98]
Anencephaly	10/10,000 pregnancies 2.6/10,000 births [24]	62–72% [25,26]	<24 h [26,27] 55 min [28]	0–14%>1 week/7% >1 year [18,29]	10 months [30] 2.5 years [31]
Thanatophoric dysplasia	0.4/10,000 [32]	Not reported	Not reported	Not reported	5 years [33] 9 years [34]
Trisomy 18	2.6/10,000 [24]	48–51% [35,36]	14 days [37]	35–65%>1 week/14–19% >1 year [18,29]	27 years [38] 30 years [39] 50 years [40]
Trisomy 13	1.2/10,000 [24]	28–46% [35,36]	10 days [37]	45–57%>1 week/14–21% >1 year [18,29]	19 year [41] 27 year [42]
Holoprosencephaly	0.5/10,000 [43]	Not reported	4–5 months [44]	71%>1 week/ 47% >1 year [29]	6 years [45] 11 years [44] 13 years [43] 19 years [46]

^aUsing recent population cohort studies where available.